Monday, October 01, 2007

Welcome: The rules!, and Introduction to physics of biological systems

Generalities

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General Biophysics

This subject is coordinated by Dr. Marta Ibañes (M.I.) and myself (Dr. Javier Buceta, J.B.). Both, together with Drs. Jose María Sancho (J.M.S.) and Ignasi Pagonabarraga (I.P.) are the lectures of this mandatory subject that is divided in different blocks. Each of us will be in charge of different parts in a coordinated way:

  • Introduction to physics in biological systems (J.B.)
  • Introduction to biology (M.I.)
  • Biophysics at the molecular scale(J.M.S.)
  • Biophysics at the cellular scale(I.P.)
  • Biophysics of populations: stochastic methods (J.B.)
  • Introduction to systems biology (M.I.)

May be some topics will appear "repeated" along the course. However, we will try to minimize redundancies and (when not possible) to focus on different aspects.

Articles

In regard of the blocks I'll teach, in each of them we will comment on different research articles. Those papers will be available for download from the blog. You MUST read and study those papers. Besides the homework you must present for the subject, continuous evaluation lies on the work you perform on those papers, class attendance (mandatory), questioning/discussion in class, and, in general, your active participation.

Homework

A short list of "easy" problems will be provided. This problems are not mandatory but a self-test. In addition, you must present a work (or works) that will be related to the papers we'll discuss in class. Although is not mandatory, I encourage you to use English both in class and in those works. Deadline for work presentation is before I start to teach the next block (December 3rd): no exceptions, no reminders!!!!. You must send me your homework via email. Homework will be available for download from the blog (see below). Work based on the research articles must preserve the style of a research article if indicated. The following structure must be followed (when possible):

  • Abstract: a summary of the idea or ideas that you discuss in the work and the main results and conclusions (~150 words max.).
  • Introduction: motivation and relevant questions to discuss and solve(~1000 words max.).
  • Methods: tools (theoretical and numerical) you used to solve your work (~500 words max.).
  • Results: results of the work and answer to the questions provided (if any).
  • Conclusions and discussion: main conclusions of the work, possible extensions, criticisms, limitations....(~500 words max.).
  • References: bibliography.
  • Supplementary material: if you consider that additional information must be provided this is the section where you can do it.

Introduction to physics in biological systems


This is the first block I'll teach for the subject of General Biophysics. It is divided in 5 classes during October (5th, 8th, 10th, 15th, and 17th) from 11:50 to 13:40. This block will be mostly focused on thermodynamics applied to biological problems from the point of view of Chemical-Physics:

  • Thermodynamics reminder
  • Introduction to kinetic theory
  • Thermodynamic potentials
  • Mass-action law
  • Introduction to non-equilibrium thermodynamics

Research articles for this block are ("click" to download, PDF format):


Homework for this block:


In addition, HERE you can download three simple problems of thermodynamics. If you have troubles solving these problems you surely need to study thermodynamics urgently. Another biological self-test: can you identify the different cellular processes that appear in this wonderful animation?. Probably you don't: no panic, by the end of the master you'll be able to.>
Finally, some bibliography:



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